Overexpression of Ras-Related C3 Botulinum Toxin Substrate 2 Radiosensitizes Melanoma Cells In Vitro and In Vivo

Figure 1

The RAC2 expression levels and the survival fraction of the 4 cell lines exposed to X-rays or carbon ion beams. (a) The RAC2 protein levels in the 4 cell lines exposed to 2 Gy X-rays or 2 Gy carbon ion beams with RAC2 knockdown or radiation-inducible RAC2 overexpression were detected by Western blot 2 hours postirradiation. (b, c) After exposure to different doses of X-rays, the survival fractions of the 4 cell lines were measured by colony forming assay. (d, e) After exposure to different doses of carbon ion beams, the survival fractions of the 4 cell lines were measured by colony forming assay. indicates a statistical significance () for comparisons between 92-NC and 92-shRAC2 or between OCM-NC and OCM-RAC2. .

(a)

(b)

(c)

(d)

(e)