Encapsulated Mulberry Fruit Extract Alleviates Changes in an Animal Model of Menopause with Metabolic Syndrome

Table 4

The effect of various doses of MME on serum estradiol level.

Treatment group	Estradiol (pg/ml)
ND + vehicle
HCHF + vehicle
OVX + HCHF + vehicle	^a,bb
OVX + HCHF + isoflavone 15 mg/kg BW
OVX + HCHF + L-carnitine 250 mg/kg BW
OVX + HCHF + MME 10 mg/kg BW
OVX + HCHF + MME 50 mg/kg BW
OVX + HCHF + MME 250 mg/kg BW

Data are presented as (/group). ^a value<0.05, compared to control rats which received normal diet and vehicle; ^bb value < 0.01, compared to normal rats which received HCHF diet and vehicle. ND: normal diet; HCHF: high-carbohydrate high-fat diet; OVX+HCHF: ovariectomized rats which received high-carbohydrate high-fat diet; MME10, 50, and 250: the microencapsulated mulberry fruits extract at doses of 10, 50, and 250 mg/kg BW, respectively.