ROS-Induced GATA4 and GATA6 Downregulation Inhibits StAR Expression in LPS-Treated Porcine Granulosa-Lutein Cells

<div>Melatonin and Vc act as ROS scavengers in pGL. (a) pGL were pretreated for 24 h with vehicle control, LPS (1000 ng/mL), or H<sub>2</sub>O<sub>2</sub> (0.4 mM), with or without melatonin (10 mM) or Vc (5 mM), respectively. Intracellular ROS were evaluated by H2DCFDA detection, and fluorescent images are shown (scale bar: 30 <i>μ</i>m). (b) Intracellular ROS fluorescence intensity was evaluated. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: ROS-Induced GATA4 and GATA6 Downregulation Inhibits StAR Expression in LPS-Treated Porcine Granulosa-Lutein Cells 