ROS-Induced GATA4 and GATA6 Downregulation Inhibits StAR Expression in LPS-Treated Porcine Granulosa-Lutein Cells

<div>Elimination of ROS with melatonin rescues the expressions of GATA4, GATA6, and StAR after treatment with LPS or H<sub>2</sub>O<sub>2</sub>. (a) pGL were treated for 24 h with vehicle control, LPS (1000 ng/mL), and LPS (1000 ng/mL) with melatonin (10 mM). StAR, GATA4, GATA6, CYP11A1, and 3<i>β</i>-HSD mRNA levels were examined by RT-qPCR. (b) pGL were treated for 24 h with vehicle control, H<sub>2</sub>O<sub>2</sub> (0.4 mM), and H<sub>2</sub>O<sub>2</sub> (0.4 mM) with melatonin (10 mM). StAR, GATA4, GATA6, CYP11A1, and 3<i>β</i>-HSD mRNA levels were examined by RT-qPCR. 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Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: ROS-Induced GATA4 and GATA6 Downregulation Inhibits StAR Expression in LPS-Treated Porcine Granulosa-Lutein Cells 