TY - JOUR A2 - Schroder, Nadja AU - Badeli, Hamidreza AU - Baghersalimi, Adel AU - Eslami, Sajjad AU - Saadat, Farshid AU - Rad, Afagh Hassanzadeh AU - Basavand, Rokhsar AU - Papkiadeh, Soghra Rafiei AU - Darbandi, Bahram AU - Kooti, Wesam AU - Peluso, Ilaria PY - 2019 DA - 2019/04/21 TI - Early Kidney Damage Markers after Deferasirox Treatment in Patients with Thalassemia Major: A Case-Control Study SP - 5461617 VL - 2019 AB - Background. The life of patients with β-thalassemia major depends on blood transfusion. Regular blood transfusion leads to hemosiderosis in their main organs. The aim of this study was to compare the effects of deferasirox and deferoxamine on renal damage in patients with β-thalassemia major. Method. The present case-control study was conducted on 60 individuals who were referred to the 17th Shahrivar Tertiary Referral Hospital in Guilan province, Iran. In this study, patients with β-thalassemia major who used deferasirox (n=21) and patients who used deferoxamine (n=19) were evaluated. The control group (n=20) was selected from healthy individuals. Serum creatinine (CREA), blood urea nitrogen (BUN), and Cystatin C were measured from blood samples. Furthermore, urinary (U.) neutrophil gelatinase-associated lipocalin (NGAL), albumin (Alb), interleukin- (IL-) 18, and Kidney Injury Molecule-1 (KIM-1) were measured by the ELISA method and normalized for U. creatinine (CREA). Results. U. NGAL, U. IL-18, and BUN biomarkers in the deferasirox group were significantly higher than those in the control group (p<0.001). U. NGAL/CREA and U. KIM-1/CREA ratios increased in both the deferoxamine and deferasirox groups compared to the control group (p<0.05). U. Alb was significantly higher in patients treated with deferoxamine than in healthy participants (p<0.05). Conclusion. The findings of this study indicate that after taking deferasirox, there was renal damage and an increase in inflammatory factors. Also, minor renal impairment was observed after deferoxamine administration, but it was not confirmed at the molecular level (U. NGAL and KIM-1). Therefore, it seems that patients who are taking these two drugs should be monitored carefully. SN - 1942-0900 UR - https://doi.org/10.1155/2019/5461617 DO - 10.1155/2019/5461617 JF - Oxidative Medicine and Cellular Longevity PB - Hindawi KW - ER -