A Meta-Analysis of Resveratrol Protects against Myocardial Ischemia/Reperfusion Injury: Evidence from Small Animal Studies and Insight into Molecular Mechanisms

Table 4

The proposed molecular and cellular mechanism of the cardioprotective effect of resveratrol in in vivo studies.

Studies	Year	Dosage	Proposed mechanism
Dong et al. [10]	2015	10 mg/L	Downregulation of inflammatory response (NALP3 inflammasome, IL-1β, IL-18) and caspase-1 expression
Cheng et al. [11]	2015	100 μmol/L	Attenuate inflammation (MPO), oxidative stress (SOD, MDA, GSH-PX) possibly via Nrf2/ARE pathway
Li et al. [12]	2014	100 μmol/L	Deactivation of TLR4/NF-κB signaling, anti-inflammation (MPO, TNF-α, NO)
Cong et al. [13]	2014	100 μmol/L	Activation of cGMP/NO signaling, anti-inflammation (MPO, TNF-α)
Du et al. [29]	2014	10 mg/L	Activation of AMPK/Kir6.2-containing K-ATP channel signaling
Shalwala et al. [28]	2014	5 mg/L	Activation of SIRT1 signaling
Naumenko et al. [30]	2013	10 μmol/L	NA
Shen et al. [31]	2006	10 μmol/L	Attenuate oxidative stress (MDA, NO)
Hung et al. [26]	2004	1 mg/L	NO-independent
Hale and Kloner [32]	2001	1.5 mg/L	NA