Metabolites of the Nitric Oxide (NO) Pathway Are Altered and Indicative of Reduced NO and Arginine Bioavailability in Patients with Cardiometabolic Diseases Complicated with Chronic Wounds of Lower Extremities: Targeted Metabolomics Approach (LC-MS/MS)

Figure 3

Wound etiology and intermediates in the arginine/NO pathway: (a) arginine, (b) citrulline, (c) ADMA, (d) SDMA, (e) arginine-to-ADMA ratio (Arg/ADMA), and (f) arginine-to-SDMA ratio (Arg/SDMA). Data are presented as means with 95% confidence intervals and analyzed using one-way ANOVA. ISCH: ischemic etiology; NEURO: neurotrophic etiology; VEN: venous stasis etiology. Numbers below the dot plots represent the mean value within a group. Letters above/below the dot plots indicate groups from which a given group mean differs significantly: A: significantly different from ISCH; B: significantly different from NEURO; C: significantly different from VEN.

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