Research Article

Metabolites of the Nitric Oxide (NO) Pathway Are Altered and Indicative of Reduced NO and Arginine Bioavailability in Patients with Cardiometabolic Diseases Complicated with Chronic Wounds of Lower Extremities: Targeted Metabolomics Approach (LC-MS/MS)

Table 1

Characteristics of the study population.

ParameterHealthy controlsPatients with cardiometabolic diseases value
Without chronic woundsWith chronic wounds

Number of patients885559
Age (yrs.), median (range)63 (50-73)64 (49-81)65 (40-87)0.086K
Sex (F/M), 33/5529/2622/370.145
FG (mg/dL), mean (95% CI)159.5 (149-179)147.2 (105-189)0.591W
HbA1C (%), mean (95% CI)7.73 (7.2-8.2)7.98 (7-8.9)0.620t
CHOL (mg/dL), median (95% CI)168 (163-177)164 (147-175)0.162M
HDL (mg/dL), median (95% CI)44.5 (40-49)35 (32-44)0.008M
LDL (mg/dL), mean (95% CI)101 (91-112)89.8 (81-99)0.104W
TG (mg/dL), mean (95% CI)148.4 (129-171)126.7 (108-148)0.156t
Creatinine (mg/dL), mean (95% CI)0.98 (0.92-1.04)0.89 (0.78-1.02)0.191W
HGB (g/dL), mean (95% CI)13.5 (13-13.9)12.9 (12.4-13.8)0.084t
CRP (mg/L), mean (95% CI)1.7 (1.3-2.3)19.6 (13.5-28.5)<0.0001t

yrs.: years; F/M: female-to-male ratio; SD: standard deviation; : number of patients; FG: fasting glucose; HbA1C: glycated hemoglobin; CHOL: total cholesterol; HDL: high-density lipoprotein cholesterol; LDL: low-density lipoprotein cholesterol; TG: triglycerides; HGB: hemoglobin; CRP: C-reactive protein; KKruskal-Wallis test; WWelch test; chi-squared test; t-test for independent samples; MMann-Whitney test.