Metabolites of the Nitric Oxide (NO) Pathway Are Altered and Indicative of Reduced NO and Arginine Bioavailability in Patients with Cardiometabolic Diseases Complicated with Chronic Wounds of Lower Extremities: Targeted Metabolomics Approach (LC-MS/MS)
Table 2
Correlation pattern between intermediates in the arginine/NO pathway and cytokines, chemokines, and growth factors.
Cytokine
Arg
Cit
ADMA
SDMA (log)
Arg/ADMA
Arg/SDMA
FGF2
0.13
-0.29
-0.17
-0.28
0.21
0.27
G-CSF
0.12
-0.35
-0.27
-0.37
0.42‡
0.41‡
GM-CSF (log)
0.06
-0.39
-0.36
-0.42‡
0.39
0.36
IL-1β
0.10
-0.27
-0.27
-0.36
0.38
0.35
IL-4
0.17
-0.32
-0.21
-0.34
0.32
0.36
IL-6 (log)
0.08
-0.30
-0.39
-0.23
0.52†
0.27
IL-8
-0.06
-0.36
-0.30
-0.34
0.28
0.23
MCP1 (log)
-0.07
-0.24
-0.10
-0.25
0.10
0.20
MIP-1α
0.07
-0.07
-0.16
-0.20
0.23
0.22
PDGF (log)
0.25
-0.21
-0.10
-0.17
0.27
0.28
TNFα (log)
0.14
-0.31
-0.32
-0.38
0.46‡
0.40
VEGF-A (log)
-0.07
-0.28
-0.37
-0.28
0.32
0.14
,, and . Data were analyzed using the Pearson test and reported as correlation coefficients .
