Review Article
Effects of Microvesicles on Cell Apoptosis under Hypoxia
Table 1
The role of MV in the tumor.
| Main role | MV origins | Acting cells | Type of action |
| Promote tumor progression | | | | Promote growth | Glioblastoma cells | Human glioma cells | MVs transport RNA and proteins | Promote tumor angiogenesis | Human lung cancer cells | Stromal cells | Express more angiogenic factors | Mediated immune escape | Human colorectal cancer cells | NK cells | MVs transport miR-126 and TGF-β | Melanoma cells | T cells | MVs transport FasL | Promote thrombosis | Human pancreatic cancer cells | Platelets | MVs transport tissue factor | Promoting normal cell apoptosis | Lung and pancreatic tumor cells | Myoblasts | MVs transport miR-21 | Inhibited tumor progression | | | | Induce tumor cell apoptosis | Platelets | Lung and colon carcinoma ectopic tumors | MVs transport miR-24 | Human hepatic stem cells | Hepatoma cells | MVs transfer miRNAs with potential antitumor activity |
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