Figure 1: Schematic diagram showing all experimental procedures. (a) Experimental protocol of PMG treatment and the determination of various parameters. (b) Metabolic syndrome induction and schedule for PMG treatment. LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostasis model assessment of insulin resistance; ACE: angiotensin-converting enzyme; HDAC3: histone deacetylase 3; PPAR-γ: peroxisome proliferator-activated receptor gamma; IL-6: interleukin-6; TNF-α: tumor necrosis factor-α; PMG50, PMG100, and PMG200: the phytosome containing the combined extracts of mulberry and ginger at a dose of 50, 100, and 200 mg·kg-1 BW, respectively.