Isolated Silymarin Flavonoids Increase Systemic and Hepatic Bilirubin Concentrations and Lower Lipoperoxidation in Mice

Table 1

Inhibitory concentrations of individual silymarin flavonoids and related compounds.

Compound	IC50 (μM)
Silybin A	>200
Silybin B	>200
Silybin AB	>200
Isosilybin A
Isosilybin B
2,3-Dehydrosilybin A	>200
2,3-Dehydrosilybin B	>200
Silychristin	>200
2,3-Dehydrosilychristin	>200
Silydianin	>200
2,3-Dehydrosilydianin	>200
Isoquercitrin
Quercetin
Taxifolin	>200

HepG2 cells were treated for 24 h with natural flavonoids in concentrations of 0.1-200 μM. IC: inhibitory concentration, measured by the MTT test.