Andrographolide Derivative AL-1 Ameliorates Dextran Sodium Sulfate-Induced Murine Colitis by Inhibiting NF-κB and MAPK Signaling Pathways

Figure 1

AL-1 attenuates colitis in the DSS-induced mice model. (a) The chemical structure of AL-1. (b) Body weight change and (c) DAI scores of C57BL/C mice given 2.5% DSS for 7 days. Mice were sacrificed on day 8, and colon length was measured (d, e). H&E-stained colon cross-sections of C57BL/C mice at day 8 (f). Total histological score was calculated as the sum of epithelial damage (g). Data are presented as the ( mice/group). compared with the control group and ^## and ^### compared with the vehicle-treated UC model group.

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