HB-EGF Ameliorates Oxidative Stress-Mediated Uterine Decidualization Damage

Figure 5

HB-EGF rescues antioxidant capacity in H₂O₂-treated stromal cells. (a–c) HB-EGF restored the activities of antioxidant enzymes (a) SOD, (b) CAT, and (c) GPX after exposure to H₂O₂. (d–f) GPX inhibitor MS impeded the induction of HB-EGF on Prl8a2 and Prl3c1 expression as well as ALP activity under oxidative stress. (g) HB-EGF had no effect on NOX activity in stromal cells under oxidative stress. (h and i) HB-EGF rescued the content of GSH in H₂O₂-induced stromal cells and restored the ratio of GSH/GSSG in H₂O₂-induced stromal cells.

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