Research Article

HB-EGF Ameliorates Oxidative Stress-Mediated Uterine Decidualization Damage

Figure 9

Schematic diagram summarizes the protective effects of HB-EGF on oxidative stress-mediated uterine decidualization damage. HB-EGF might induce proliferation and differentiation of uterine stromal cells through targeting Ccnd3 and Cdk4 and prevent the impairment of oxidative stress on uterine decidualization by improving the antioxidant capacity of SOD, CAT, GPX, and GSH and restoring the mitochondrial function. Meanwhile, HB-EGF ameliorated oxidative stress-induced stromal cell apoptosis via Caspase-3, Bax, and Bcl-2.