Research Article

Increased HIF-1α in Knee Osteoarthritis Aggravate Synovial Fibrosis via Fibroblast-Like Synoviocyte Pyroptosis

Figure 4

Inhibition of FLS pyroptosis may alleviate fibrosis. (a) Representative synovial tissues stained with pimonidazole, 400x, scale . The Vehicle group and the GSDMD siRNA group showed similar intracellular hypoxia. (b) Relative gene expressions of TGF-β, COL1A1, PLOD2, and TIMP1 in the GSDMD siRNA group were downregulated compared with those in the Vehicle group (). (c) Typical protein bands for each group. (d) Protein levels of TGF-β, COL1A1, PLOD2, and TIMP1 in the GSDMD siRNA group were downregulated compared with those in the Vehicle group ().
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