Dietary Glycotoxins Impair Hepatic Lipidemic Profile in Diet-Induced Obese Rats Causing Hepatic Oxidative Stress and Insulin Resistance
Total phospholipid content in the liver similar in all experimental groups (a). Rats supplemented with MG had a trend to reduced total plasmenyls levels (b), while its supplementation specifically to obese rats (HFDMG group) has led to a further decrease in polyunsaturated cardiolipins (d). Oxidative stress was confirmed through dihydroethidium (DHE) staining. (i) shows DHE staining (red), nuclei staining using DAPI (blue), and merged images. DHE was used to stain superoxide anion, and increased reactivity was observed in HFDMG liver sections (50x), especially in the portal spaces (white arrows). The bottom image shows a section of an HFDMG liver (100x) with increased reactivity around the portal spaces (white arrows). No reactivity was found in the same area of livers from obese rats without glycotoxin supplementation (white asterisk). Ct: Wistar 12 m; MG: Wistar + MG supplementation; HFD: HF diet-fed Wistar; HFDMG: HF diet-fed Wistar + MG supplementation. Bars represent . vs. Ct; # vs. MG; $ vs. HFD. 1 symbol .
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