Mitophagy and Oxidative Stress in Cancer and Aging: Focus on Sirtuins and Nanomaterials

Figure 3

Sequence and molecular details of the selective mitophagy. When mitochondria undergo decrease in membrane potential (or different stress stimuli), PINK1, localized on the mitochondrial membrane, recruits Parkin that polyubiquitinates MOM protein and induces the autophagosome formation. Then, lysosome fuses with the autophagosome (autophagolysosome) and the degraded material can be recycled or disposed.