Mitophagy and Oxidative Stress in Cancer and Aging: Focus on Sirtuins and Nanomaterials

Table 2

Mitochondrial receptors and their ligands involved in the mitophagic process.

Receptor	Localization	Ligands (interaction)	Species	Reference
ATG32	Outer mitochondrial membrane	Atg8, Atg11	Yeast	[22]
NIX/BNIP3L	Outer mitochondrial membrane	LC3	Mammals	[23–25]
BCL2L13	Outer mitochondrial membrane	LC3	Mammals	[26]
FUNDC1	Outer mitochondrial membrane	LC3	Mammals	[27]
Cardiolipin	Mitochondrial inner membrane, any damage to mitochondria, or depolarization of its membrane results in the translocation to outer mitochondrial membrane	LC3	Mammals	[28]
PHB 2	Inner mitochondrial membrane	LC3	Mammals	[29]
Parkin	Normally in the cytosol, it is translocated to the outer mitochondrial membrane upon depolarization	AMBRA1, LC3	Mammals	[30]
BCL2L13	Outer mitochondrial membrane	LC3	Mammals	[31]
FKBP8	Outer mitochondrial membrane	LC3	Mammals	[32]
SMURF1	Cytoplasmatic, colocalized with damaged mitochondria	LC3?	Mammals
BNIP3	Outer mitochondrial membrane	LC3	Mammals	[33]
NLRX1	Outer mitochondrial membrane	LC3	Mammals	[34]