Antitumoral and Immunomodulatory Effect of Mahonia aquifolium Extracts

Table 2

Half inhibitory concentrations (IC50) of M. aquifolium extracts 1-5 on tumor and normal cell lines after 24-hour in vitro treatment, expressed as of logIC50. The median values were extracted from the dose-response sigmoid curve (logarithm of concentration versus growth inhibition percent, analysis performed with the GraphPad Prism 5 software) (see supplemental data Figure 16).

	Extract 1		Extract 2		Extract 3		Extract 4		Extract 5
	Median values	SD	Median values	SD	Median values	SD	Median values	SD	Median values	SD
DLD-1	9.67	0.05	14.26	0.07	56.05	0.11	67.01	0.08	32.63	0.10
A2780	12.72	0.06	22.59	0.08	72.23	0.11	57.16	0.09	52.59	0.12
A375	15.76	0.05	19.85	0.06	70.89	0.05	26.86	0.08	36.42	0.06
BJ	11.03	0.04	25.06	0.05	53.55	0.15	102.81	0.22	73.01	0.11

The values above 50 μg/mL are hypothetical; they were obtained by extrapolation, given that the highest concentration used in the experiment was 50 μg/mL.