Methane-Rich Saline Counteracts Cholestasis-Induced Liver Damage via Regulating the TLR4/NF-κB/NLRP3 Inflammasome Pathway

Figure 1

MRS alleviated tissue damage and organ dysfunction in the livers of BDL rats. Rats were treated by intraperitoneal administration (10 mL/kg) of MRS for 7 days after BDL. Liver tissues and blood samples were collected 7 days after the BDL operation. (a) H&E staining (scale bars: 100 μm and 50 μm). (b) Necrotic areas. (c) Histological scores. (d–f) Serum levels of TBIL, ALT, and AST (. Data are shown as the . versus the sham control group; ^# versus the sham control group; ^€ versus the MRS control group; ^$ versus the MRS control group; ^& versus the BDL+NS group; ^γ versus the BDL+NS group).

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