Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses

Table 3

Isolated compounds from essential oils and/or synthesized compounds derivated from essential oils actives against Aedes aegypti.

Classes	Chemical Structure of isolated or synthesized compound		Reference
Monoterpene hydrocarbons	3-Carene (119)	10.7 μg/mL	[213]
		150 ppm	[214]
		25.3 μg/mL	[215]
	α-Terpinene (183)	14.7 μg/mL	[213]
		14.7 μg/mL	[216]
		28.1 μg/mL	[215]
	γ-Terpinene (64)	37.2 μg/mL	[213]
		30.7 μg/mL	[216]
		26.8 μg/mL	[215]
		56 ppm	[214]
	p-Cymene (11)	43.3 μg/mL	[213]
		51 ppm	[217]
		23.3 ppm	[218]
		19.2 μg/mL	[216]
		37.1 μg/mL	[215]
	β-Pinene (39)	183.8 μg/mL	[213]
	R-Limonene (8)	27 ppm	[214]
		17.8 μL L^−1	[219]
	S-Limonene (8)	30 ppm	[214]
		33.9 ppm	[220]
		13 μL L^−1	[219]
	RS-Limonene (8)	517 ppm	[214]
		18.1 μg/mL	[216]
	β-Myrcene (61)	35.8 μg/mL	[215]
		120.3 ppm	[221]
	α-Pinene (118)	>50 μg/mL	[216]
		79.1 μg/mL	[215]
	Terpinolene (141)	28.4 μg/mL	[216]
		32.1 μg/mL	[215]
	α-Phellandrene (143)	39.3 μg/mL^−1	[222]
		16.6 μg/mL	[216]
	Camphene (15)	>400 μg/mL	[213]
	(−)-Camphene (15)	220 ppm	[217]
	(+)-Camphene (15)	406 ppm	[217]
Oxygenated monoterpenes	(−)-α-Terpineol (111)	>400 μg/mL	[213]
		>50 μg/mL	[216]
	(−)-Terpinen-4-ol (103)	>400 μg/mL	[213]
		>50 μg/mL	[216]
		>100 μg/mL	[215]
	Thymol (1)	81 ppm	[217]
		17.5 ppm	[218]
		13.9 ppm	[223]
	Carvacrol (10)	69 ppm	[217]
		20.13 ppm	[223]
	Borneol (112)	610 ppm	[217]
	Isoborneol (178)	598 ppm	[217]
	Camphor (14)	657 ppm	[217]
	R-Carvone (13)	152 ppm	[217]
		129.1 ppm	[217]
	S-Carvone (13)	124 ppm	[217]
	RS-Carvone (13)	118 ppm	[214]
	Isopulegol (184)	297 ppm	[214]
	Neoisopulegol (185)	554 ppm	[214]
	Menthol (130)	404 ppm	[214]
	Menthone (132)	508 ppm	[214]
	1,2-Carvone oxide (186)	219 ppm	[214]
	(+)-Pulegone (128)	188.1 ppm	[220]
	1,4-Cineole (187)	751 ppm	[217]
	1,8-Cineole (124)	1419 ppm	[217]
		>100 μg/mL^−1	[222]
		>50 μg/mL	[216]
	5-Norbornene-2,2-dimethanol (188)	785 ppm	[217]
	5-Norbornene-2-endo,3-endo-dimethanol (189)	1407 ppm	[217]
	5-Norbornene-2-exo,3-exo-dimethanol (190)	717 ppm	[217]
	5-Norbornene-2-ol (191)	759 ppm	[217]
	(1R,2R,5R)-2-Methyl-5-(1-methylethenyl)-3-oxo-cyclohex-anecarbonitrile	412 ppm	[214]
	Carvacrol methyl ether (192)	40.6 ppm	[223]
	Umbellulone (158)	32.3 ppm	[221]
	Vanillin (193)	513 ppm	[217]
	α-Terpinyl acetate (194)	>50 μg/mL	[216]
	Rotundifolone (88)	62.5 ppm	[220]
	Pulegone epoxide (195)	1116.2 ppm	[220]
	(−)-Carvone epoxide (196)	217.5 ppm	[220]
	(+)-Carvone epoxide (197)	254.6 ppm	[220]
	(+)-Limonene epoxide (90)	525.0 ppm	[220]
	(−)-Limonene epoxide (90)	522.5 ppm	[220]
	(−)-Perill aldehyde (92)	115.8 ppm	[220]
	Perillaldehyde epoxide (198)	715.1 ppm	[220]
	trans-Isopulegone (199)	538.8 ppm	[220]
	trans-dihydrocarvone (200)	361.3 ppm	[220]
	Hydroxycarvone (199)	1470.9 ppm	[220]
	Hydroxydihydrocarvone (200)	1628.2 ppm	[220]
	Acetoxycarvotanacetone (201)	230.7 ppm	[220]
Oxygenated sesquiterpenes	Elemol (52)	>100 μg/mL	[215]
	β-Eudesmol (59)	>50 μg/mL	[224]
		>100 μg/mL	[215]
Diterpenes	16-Kaurene (202)	57 μg/mL	[213]
		57.0 μg/ml	[217]
Phenylpropanoids	Estragole (74)	46.4 μL L^−1	[219]
	Eugenol (2)	88 ppm	[217]
		93.3 ppm	[224]
		71.9 ppm	[224]
		23.4 ppm	[223]
	1-Acetate-2-methoxy-4-(2-propen-1-yl)-phenol	113.3 ppm	[224]
		107.7 ppm	[224]
	1-Propanoate-2-methoxy-4-(2-propen-1-yl)-phenol	97.2 ppm	[224]
		62.3 ppm	[224]
	1-Benzoate-2-methoxy-4-(2-propen-1-yl)-phenol	706.8 ppm	[224]
		723.2 ppm	[224]
	1-Benzoate-2-methoxy-4-(3-hydroxypropyl)-phenol	166 ppm	[224]
		151.1 ppm	[224]
	1,2-Dimethoxy-4-(2-propen-1-yl)-benzene	107.3 ppm	[224]
		101.4 ppm	[224]
	1-Ethoxy-2-methoxy-4-(2-propen-1-yl)-benzene	67.2 ppm	[224]
		76.4 ppm	[224]
	1-{[(1,1-Dimethylethyl)dimethylsilyl]oxy}-2-methoxy-4-(2-propen-1-yl)-benzene	278.9 ppm	[224]
		274.5 ppm	[224]
	4-Hydroxy-3-methoxy-benzenepropanol	1415.1 ppm	[224]
		1614.9 ppm	[224]
	2-[2-Methoxy-4-(2-propen-1-yl)phenoxy] acetic acid	295.9 ppm	[224]
		240.7 ppm	[224]
	Methyleugenol (171)	36.5 ppm	[221]
	trans-Anethole (153)	29.3 μL L^−1	[219]
Others	Phenol (203)	194 ppm	[217]
	1-Dodecanol (204)	5.2 ppm	[221]
	1-Tridecanol (205)	2.1 ppm	[221]
	Allyl cis-1-propenyl disulfide	15.35 ppm	[225]
	Allyl methyl disulfide	>200 ppm	[225]
		>200 ppm	[26]
	Allyl methyl trisulfide	>200 ppm	[225]
	Dimethyl tetrasulfide	>200 ppm	[226]
	Dimethyl trisulfide	>200 ppm	[225]
		>200 ppm	[226]
	Dipropyl trisulfide	>200 ppm	[225]
		>200 ppm	[226]
	Methlyl propyl trisulfide	19.38 ppm	[226]
	Catechol (206)	243 ppm	[217]
	Guaiacol (207)	177 ppm	[217]
	Resorcinol (208)	577 ppm	[217]
	Salicylaldehyde (209)	137 ppm	[217]