Sex Differences in Age-Associated Type 2 Diabetes in Rats—Role of Estrogens and Oxidative Stress

Figure 4

Type 2 diabetic female rats are protected against free radical production compared with type 2 diabetic male rats. Protective role of estrogen replacement therapy. (a) Mitochondrial hydrogen peroxide production in male WISTAR (), male GK (), female WISTAR (), and female GK (). The data are shown as . The statistical significance is expressed as for male WISTAR versus male GK, for male GK versus female GK, and for male WISTAR versus female WISTAR. (b) Mitochondrial hydrogen peroxide production in female WISTAR (), female GK (), ovariectomized female GK (), and ovariectomized female GK + estradiol replacement (). The data are shown as . The statistical significance is expressed as for WISTAR versus GK OVX, for GK versus GK OVX, and for GK OVX versus GK OVX + E2. (c) Xanthine oxidase activity levels in plasma of male WISTAR (), male GK (), female WISTAR (), and female GK (). The data are shown as . The statistical significance is expressed as for female GK versus male GK, for female GK versus female WISTAR, and for female WISTAR versus male WISTAR.

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