Research Article

Sex Differences in Age-Associated Type 2 Diabetes in Rats—Role of Estrogens and Oxidative Stress

Figure 5

Type 2 diabetic female rats show lower levels of mitochondrial oxidative stress-related parameters than type 2 male diabetic rats. Protective role of estrogen replacement therapy (a) GSSG/GSH100 levels in hepatic mitochondria of male GK and female GK. The data are shown as ( for both groups). The statistical significance is expressed as . (b) GSSG/GSH100 levels in hepatic mitochondria of female GK (), ovariectomized female GK (), and ovariectomized female GK + estradiol replacement (). The data are shown as . The statistical significance is expressed as for GK ovx versus GK OVX + E2 and for GK versus GK OVX. (c) MDA levels in hepatic mitochondria of male GK and female GK. The data are shown as ( for both groups). The statistical significance is expressed as . (d) MDA levels in hepatic mitochondria of female GK (), ovariectomized female GK (), and ovariectomized female GK + estradiol replacement (). The data are shown as .
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