Increased Oxidative Stress Induced by Rubus Bioactive Compounds Induce Apoptotic Cell Death in Human Breast Cancer Cells
Effect of C1 and C2 on ROS production. ROS production were analysed by DCFH-DA staining in MCF-7 cells: (a) control; (b) positive control: H2O2; (c) C1: 4.69 μg/mL treated; (d) C2: 8.36 μg/mL treated. The green color indicates the fluorescence of detected ROS production and blue color indicates the nuclear stain-DAPI. C1-treated cells showed increased ROS production than C2-treated cells. (e) Quantitative ROS production analysis using ELISA showing significant ROS production upon treatment with C1 () and C2 ().
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