Cardiac Rehabilitation Increases SIRT1 Activity and β-Hydroxybutyrate Levels and Decreases Oxidative Stress in Patients with HF with Preserved Ejection Fraction
Changes in the control and ET-CR groups of Sirt1 activity, NAD+, NADH levels, and NAD+/NADH ratio from baseline to 4 weeks after the study start. The ET-CR was able to induce a significant increase in NAD+ (a), Sirt1 activity (b), and NAD+/NADH ratio (c) (all ), associated with a reduction in NADH levels (d) (), expressed as the difference between the levels after 4 weeks minus the levels at baseline.
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