Cardiac Rehabilitation Increases SIRT1 Activity and β-Hydroxybutyrate Levels and Decreases Oxidative Stress in Patients with HF with Preserved Ejection Fraction

Table 3

Changes in oxidant/antioxidant parameters in HFpEF controls and HFpEF patients who underwent ET-CR.

Variables	Ctr			ET-CR
	Baseline	After 4 weeks		Baseline	After 4 weeks
SIRT1 activity (AU)			0.560			<0.0001
βOHB (μmol/L)			0.280			<0.0001
Ox-LDL (pg/mL)			0.492			<0.0001
TEAC (mmol Trolox Equiv/L)			0.075			<0.0001
NAD^+			0.136			<0.0001
NADH			0.090			<0.001
NAD^+/NADH			0.115			<0.0001

ET-CR: exercise training-based cardiac rehabilitation; βOHB: β-hydroxybutyrate; Ox-LDL: Oxidized Low-Density Lipoprotein. CR vs. Ctr after 4 weeks, .