The Alexipharmic Mechanisms of Five Licorice Ingredients Involved in CYP450 and Nrf2 Pathways in Paraquat-Induced Mice Acute Lung Injury

Figure 11

A549 and HepG2 cells more sensitive to PQ with Nrf2 and CYP3A4 inhibitor. (a) HepG2 cell pretreatment with 10 μM ketoconazole for 4 h and exposure to 0-40 μM PQ for 24 h and HepG2 cell exposure to 0-40 μM PQ for 24 h. (b) Cell viability. A549 cells and Nrf2 knockdown A549 cells () were incubated with the indicated concentrations of PQ for 24 h. All data are expressed as the error; . CTR: control. and vs. A549 and HepG2 group; and vs. control group.

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