|
| Feature | Ref. |
|
| Structural domains |
| Ankyrin repeats | [123] |
| Coiled coil |
| Protein destabilization motif (PEST) |
| Nuclear localization signal (NLS) |
| Posttranslational modifications |
| Phosphorylation by Akt2 kinase | [15] |
| Proteolytic cleavage by μ-calpain | [9] |
| Expression profile |
| [4, 19, 123, 124] |
| Type I (slow) skeletal muscle fibers | [8, 123] |
| Localized in nuclei of myoblasts and cytoplasm of myotubes | [123] |
| Migrate from myofibrils to nucleus after muscle injury | [10] |
| Proposed functions |
| Stress response in muscle (stretch, denervation, eccentric contractions, fatiguing jumping and other types of exercise, and injury) | [8, 10, 16, 46, 47, 49, 50, 55] |
| Muscle adaptation | [7, 10, 16, 20, 46, 47, 49, 50, 125, 126] |
| Transcriptional regulation | [1, 10] |
| Communication between the sarcoplasm and the nucleus | [1] |
| Myogenesis and myogenic differentiation | [11, 13, 14] |
| Inflammatory response | [12] |
| Interacting proteins |
| Titin | [7] |
| Telethonin | [1] |
| ZASP | [30] |
| Calpain 3 | [9] |
| Akt2 | [15] |
| A-type lamins (lamin A, prelamin A, and lamin C) | [98] |
| Proteins with PDZ and SH3 domains, including ZO-1 and β1-syntrophin | [20] |
| Transcription factors, including YB1, p53, PML, PAX6, NFIL3, and MECP2 | [20] |
| Pathways affected by Ankrd2 silencing in human myoblasts |
| Intercellular communication | [20] |
| Cytokine-cytokine receptor interaction |
| Focal adhesion |
| Tight junction |
| Gap junction |
| Regulation of actin cytoskeleton |
| Signaling involved in intracellular communication |
| Calcium |
| Insulin |
| MAPK |
| p53 |
| TGF-β |
| Wnt |
|
