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Oxidative Medicine and Cellular Longevity
Volume 2019, Article ID 7480512, 20 pages
Review Article

Antioxidative Property and Molecular Mechanisms Underlying Geniposide-Mediated Therapeutic Effects in Diabetes Mellitus and Cardiovascular Disease

Ning Li,1,2,3 Ling Li,4 Haiming Wu,1,2,3 and Heng Zhou1,2,3

1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
2Cardiovascular Research Institute, Wuhan University, Wuhan 430060, China
3Hubei Key Laboratory of Cardiology, Wuhan 430060, China
4Institute of Hepatobiliary Diseases of Wuhan University, Zhongnan Hospital of Wuhan University Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei 430071, China

Correspondence should be addressed to Heng Zhou; moc.liamg@gnehuohzhz

Received 23 December 2018; Revised 7 February 2019; Accepted 13 February 2019; Published 4 April 2019

Academic Editor: Claudia Penna

Copyright © 2019 Ning Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Geniposide, an iridoid glucoside, is a major component in the fruit of Gardenia jasminoides Ellis (Gardenia fruits). Geniposide has been experimentally proved to possess multiple pharmacological actions involving antioxidative stress, anti-inflammatory, antiapoptosis, antiangiogenesis, antiendoplasmic reticulum stress (ERS), etc. In vitro and in vivo studies have further identified the value of geniposide in a spectrum of preclinical models of diabetes mellitus (DM) and cardiovascular disorders. The antioxidative property of geniposide should be attributed to the result of either the inhibition of numerous pathological processes or the activation of various proteins associated with cell survival or a combination of both. In this review, we will summarize the available knowledge on the antioxidative property and protective effects of geniposide in DM and cardiovascular disease in the literature and discuss antioxidant mechanisms as well as its potential applications in clinic.