Multiorgan Development of Oxidative and Nitrosative Stress in LPS-Induced Endotoxemia in C57Bl/6 Mice: DHE-Based In Vivo Approach

Table 1

DHE, 2-OH-E⁺, and E⁺ detected in tissues after injection of DHE (i.v.) in a murine model of endotoxemia, 6 and 12 hours after LPS challenge.

	Tissue	Control	LPS 6 h	LPS 12 h
DHE (pg/mg protein)	Liver	()	()	()
	Lung	()	()	()
	Kidney	<LOD	<LOD	<LOD
	Brain	<LOD	<LOD	<LOD
2-OH-E^+ (pg/mg protein)	Liver	()	()	()
	Lung	()	()	()
	Kidney	()	()	()
	Brain	< LOD	()	0.31 ()
E^+ (pg/mg protein)	Liver	()	()	()
	Lung	()	()	()
	Kidney	()	()	()
	Brain	()	()	()

Data are presented as . Results of Student’s-test vs. control (in bold):, , , and .