Oxidative Medicine and Cellular Longevity / 2019 / Article / Fig 4

Research Article

Protective Effect of Methane-Rich Saline on Acetic Acid-Induced Ulcerative Colitis via Blocking the TLR4/NF-κB/MAPK Pathway and Promoting IL-10/JAK1/STAT3-Mediated Anti-inflammatory Response

Figure 4

Treatment with MRS suppressed oxidative stress induced by acetic acid. Mice were administered with MRS at a dose of 1 or 10 ml/kg by gastric gavage for a week before colitis establishment. SASP was used as a positive control at a dose of 500 mg/kg. Colitis was induced by acetic acid solution () injection into the lumen of the colon intrarectally with a volume of 1 ml and dose of 5% except for the sham group. Colon sections were isolated to investigate the markers of oxidative stress including (a) MDA, (b) MPO, (c) SOD, and (d) GSH. Data were expressed as . , , , and .