Oxidative Medicine and Cellular Longevity / 2019 / Article / Fig 1

Research Article

Differential Modulation of NF-κB in Neurons and Astrocytes Underlies Neuroprotection and Antigliosis Activity of Natural Antioxidant Molecules

Figure 1

Reduction of astrocyte proliferation by antioxidant molecules. (a) Cell counts by trypan blue exclusion in astrocytes treated with TNFα (10 ng/ml) or LPS (1 μg/ml) and the effect of cotreatment with RSV (10 μM). (b, c) Cell numbers in astrocytes treated with LPS (1 μg/ml) and the effect of cotreatment with QRC (10 μM), ALA (10 μM), or CRC (10 μM) (b) and LYC (10 μM), OLP (100 μg/ml), NAC (300 μM), or GTE (12.5 μg/ml) (c). (d) Effect of the pool on TNFα- or LPS-induced proliferation of astrocytes. Data in (a–d) are the of five independent experiments. (e) Effect of antioxidants at low doses used in the pool. (f) BrdU incorporation in cortical astrocytes stimulated with LPS (1 μg/ml) for 7 days and the antiproliferative effect of the indicated antioxidants and the pool. Data, expressed as percent of CTR, are the of three independent experiments, each performed in duplicate. , , and versus CTR (ANOVA and Dunnett’s multiple comparison test).

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