Review Article
Emerging Perspective: Role of Increased ROS and Redox Imbalance in Skin Carcinogenesis
Figure 1
The effects of different concentrations of ROS on cells. (a) ROS, derived from mitochondria, NOXs, etc., mainly contain H2O2, O2•-, •OH, and others. Scavenging involves the antioxidation system, such as SOD, CAT, TRX/PRX, and vitamins. Low doses of ROS production and scavenging are in a dynamic equilibrium, which is beneficial to the physiological function of normal cells. (b) High-level ROS encourage cell variation and conversion into malignant cells. The production of ROS and antioxidation ability in tumor cells are both increased in various degrees, but cancer cells tend to be in a higher oxidation environment. (c) Toxic-dose ROS cause cell death or apoptosis and is also the killer of cancer cells.
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