Decreased Nuclear Ascorbate Accumulation Accompanied with Altered Genomic Methylation Pattern in Fibroblasts from Arterial Tortuosity Syndrome Patients

Figure 6

Compartmentalization-dependent effect of vitamin C on epigenetic regulation. Vitamin C is transported as dehydroascorbic acid (DHA) by GLUT10 into the endoplasmic reticulum (ER) lumen and in the nucleoplasm. Having been reduced to ascorbate (AA), it can serve as a cofactor for Fe²⁺/2-oxoglutarate-dependent dioxygenases, catalyzing (among others) histone and DNA demethylation. NR, nucleoplasmic reticulum.