FA-97, a New Synthetic Caffeic Acid Phenethyl Ester Derivative, Protects against Oxidative Stress-Mediated Neuronal Cell Apoptosis and Scopolamine-Induced Cognitive Impairment by Activating Nrf2/HO-1 Signaling

Figure 7

Effect of FA-97 on the neuron function and cholinergic system in scopolamine-treated mouse brain. (a) Representative images of the Nissl-stained neurons in CA1 and CA3 areas are shown. (b) The quantitative analysis of the relative number of survival neurons in each section based on the Nissl-staining assay. (c, d) The expressions of Bax, Bcl-2, and Cytochrome c in the hippocampus and cortex were measured by Western blot analysis. (e–g) The relative acetylcholine (ACh) level (e), acetylcholinesterase (AChE) activity (f), and acetyltransferase (ChAT) activity (g) in the hippocampus and cortex were measured according to the kit manufacturer’s instructions. The results are representative of three independent experiments and expressed as . and compared with the control group; and compared with the SCOP-treated group.

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