Green Tea Extract Ameliorates Ischemia-Induced Retinal Ganglion Cell Degeneration in Rats

Figure 1

Schematic diagram of ischemic reperfusion, green tea extract treatments, and experimental assessments in rats. The rats were anesthetized, and ischemic reperfusion injury was induced by the infusion of sterile saline for 2 hours with IOP elevation to 75 mmHg. The rats were intragastrically fed 4 times with 275 mg/kg green tea extract (GTE) at 2, 6, 30, and 46 hours after ischemic reperfusion injury. Protein expression was evaluated on day 2. Retinal ganglion cell (RGC) survival and function were determined on day 14 after ischemic reperfusion injury.