Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer’s Disease?

Figure 1

Physiologically, α-LA acts as a cofactor for enzymatic complexes during the oxidative phosphorylation process, such as pyruvate dehydrogenase (PDH), where α-LA residues are found in the dihydrofolipoamide acetyltransferase (E2) chain. Similarly activities occur with α-ketoglutarate dehydrogenase (KGDH) and branched chain α-ketoglutarate dehydrogenase (BCKDH) mitochondrial complexes. Thus, α-LA plays an important role in normal metabolic performance. This figure used elements from Servier Medical Art (https://www.servier.com).