Sodium Sulfite Exacerbates Allograft Vasculopathy and Affects Tryptophan Breakdown in Murine Heterotopic Aortic Transplantation
Table 3
mRNA expression of Vcam-1 and P-selectin in aortic grafts in comparison to syngeneic controls (upper rows) and in comparison to allogeneic, untreated controls (lower rows).
Syngeneic
Allogeneic
Sodium sulfite (0.1 M)
Sodium sulfite (0.01 M)
Sodium sulfate (0.1 M)
Relative expression compared to syngeneic recipients
Vcam-1
Relative exp.
1
2.46
7.11
2.91
2.54
SD
1.18–4.74
3.61–14.0
1.61–6.07
1.51–4.71
95% C.I.
0.52–9.71
1.66–26.8
0.70–9.16
0.70–6.96
p(H1)
0.012
0.001
0.003
0.004
P-selectin
Relative exp.
1
1.63
3.83
1.57
1.05
SD
1.15–2.32
2.22–6.84
0.76–2. 90
0.41–2.20
95% C.I.
0.85–3.26
1.69–10.1
0.45–5.23
0.14–2.71
p(H1)
0.005
0.002
0.109
0.900
Relative expression compared to allogeneic recipients
Vcam-1
relative exp.
1
2.89
1.19
1.04
SD
1.69–4.62
0.73–1.85
0.66–1.49
95% C.I.
1.36–6.47
0.51–3.21
0.57–1.94
p(H1)
<0.001
0.403
0.820
P-selectin
Relative exp.
1
2.35
0.96
0.65
SD
1.39–4.28
0.47–1.62
0.27–1.30
95% C.I.
0.93–5.92
0.32–3.15
0.10–1.58
p(H1)
0.001
0.877
0.272
SD = standard deviation; C.I. = confidence interval; p(H1) = hypothesis test value, significant if <0.05, .
