Review Article

The Beneficial Roles of SIRT1 in Drug-Induced Liver Injury

Figure 4

Effect of SIRT1 on maintaining cellular physiology in DILI. By preventing the generation of reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, and mitochondria dysfunction, SIRT1 blocks the damage induced by p66Shc, Ca2+, and cytochrome C (CytC).