Review Article

The Beneficial Roles of SIRT1 in Drug-Induced Liver Injury

Table 1

Compounds that alleviate drug-induced hepatotoxicity.

CompoundsToxicMechanismsRef.
NameDosageNameDosage

Dioscin80, 40, and 20 mg/kg (mice)
60, 30, and 15 mg/kg (rats)
DMN14 mg/mg (mice)
10 mg/mg (rats)
SIRT1↑, Nrf2↑, and Bcl-2↑
p53↓, Fas↓, and FasL↓
[99]
GSO3.7 g/kg (rats)CCl41 ml/kg (rats)SIRT1↑
NF-κB↓, CYP2E1↓
[100]
Luteolin100 mg/kg (mice)HgCl24 mg/kg (mice)SIRT1↑, Nrf2↑
p38↓, TNF-α
[72]
SalB15, 30 mg/kg (rats)Ethanol6 g/kg (rats)SIRT1↑
p53↓, NF-κB↓
[96]
RUE100 mg/kg (mice)Ethanol1 g/kg (mice)SIRT1↑, AMPK↑
p65↓, SREBP-1↓
[89]
MFA5, 10, and 10 mg/kg (rats)Ethanol5% (, rats)SIRT1↑, PPAR-α
MAPK↓, p-ACC↓
[67]
TQ20, 40 mg/kg (mice)Ethanol5 g/kg (mice)SIRT1↑, AMPK↑[74]
CA20, 40 mg/kg (rats)Ethanol6 g/kg (rats)SIRT1↑
p66Shc↓
[105]
Resveratrol500 mg/kg (Rats)HFCS20% (, rats)SIRT1↑, IRS-1↑
iNOS↓
[77]
Quercetin
SRT1720
Resveratrol
50 mg/kg (rats)
5 mg/kg (rats)
2.3 mg/kg (rats)
D-GalN
LPS
400 mg/kg (rats)
10 μg/kg (rats)
SIRT1↑, HO-1↑
Bilirubin↓
[35]
Melatonin0.5 μM (HepG2)Cadmium2.5, 5, and 10 μM (HepG2)SIRT1↑
Ac-PGC-1α
[88]
STR172010, 20 mg/kg (mice)EE10 mg/kg (mice)SIRT1↑, FXR/HNF1α
IL-6↓, TNF-α
[103]
SalA15, 25 mg/kg (mice)ConA18 mg/kg (mice)SIRT1↑
p66Shc↓
[97]
Resveratrol25, 50, and 100 mg/kg (mice)APAP400 mg/kg (mice)SIRT1↑, cyclin D1↑
p53↓, CYP2E1↓
[23]
Resveratrol
CAY10591
30 mg/kg (rats)
0.5 mg/kg (rats)
APAP1 g/kg (rats)SIRT1↑[24]
Resveratrol100 mg/kg (mice)INH
RIF
50 mg/kg (mice)
100 mg/kg (mice)
SIRT1↑
PPAR-γ
[71]

DMN: dimethylnitrosamine; CCl4: carbon tetrachloride; GSO: grape seed oil; MFA: methyl ferulic acid; EE: 17α-ethinylestradiol; RUE: root bark of Ulmus davidiana var. japonica; D-GalN: D-galactosamine; LPS: lipopolysaccharide; TQ: thymoquinone; CA: carnosic acid; HFCS: high-fructose corn syrup; CLP: cecal ligation and puncture; SalB: salvianolic acid B; SalA: salvianolic acid A; ConA: concanavalin; Ref.: reference.