Curcumin Inhibits the PERK-eIF2<i>α</i>-CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress-induced Rat Chondrocytes and Ameliorates Osteoarthritis Progression in a Rat Model

<div>EX527 abrogated the inhibiting effect of curcumin on oxidative stress-induced ER stress in chondrocytes. (a, b) The protein expression levels of CHOP, GRP78, and ATF4 were evaluated by western blot analysis. (c, d) The representative CHOP was detected by the immunofluorescence counterstained with DAPI staining (bar: 10 <i>μ</i>m). The fluorescence intensity of CHOP was analyzed by ImageJ. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Curcumin Inhibits the PERK-eIF2<i>α</i>-CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress-induced Rat Chondrocytes and Ameliorates Osteoarthritis Progression in a Rat Model 

Figure 5 | Curcumin Inhibits the PERK-eIF2α-CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress-induced Rat Chondrocytes and Ameliorates Osteoarthritis Progression in a Rat Model 