Research Article

Metformin Protects against Oxidative Stress Injury Induced by Ischemia/Reperfusion via Regulation of the lncRNA-H19/miR-148a-3p/Rock2 Axis

Figure 6

lncRNA-H19 regulates Rock2 expression by miR-148a-3p in OGD/R-induced N2a cells. (a, c) The mRNA and protein expression of Rock2 was decreased in OGD/R-induced N2a cells, and cell transfection of pcDNA3.1-H19 upregulated Rock2 expression in OGD/R-induced N2a cells. However, miR-148a-3p mimic cotransfected into N2a cells reversed the effect of pcDNA3.1-H19 on Rock2 expression. (b, d) The mRNA and protein expression of Rock2 was decreased in N2a cell transfection of siRNA-H19, but miR-148a-3p inhibitor-cotransfected N2a cells reversed the Rock2 expression. Data are represented as ; and .
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