Sargassum fusiforme Fucoidan SP2 Extends the Lifespan of Drosophila melanogaster by Upregulating the Nrf2-Mediated Antioxidant Signaling Pathway

Figure 4

SP2-supplemented diet slows down the decline in the antioxidant capacity of D. melanogaster during the aging process. The fruit flies were reared on a medium containing no SP2 (Con) or different concentrations of SP2 (0.4 g/L (LSP), 0.8 g/L (MSP), and 1.6 g/L (HSP)), and their antioxidant capacity was analyzed at different ages. SOD activity (a, b); GSH-Px level (c, d); CAT activity (e, f); CSSG content (g, h); MDA content (i, j), and GSH/GSSG (k, l). The antioxidant capacity was determined for both male flies (a, d, e, g, i, and k) and female flies (b, d, f, h, j, and l). Data are shown as from three determinations, each used the extract obtained from 25 flies. “,” “,” and “” indicate a significant difference at the , , and levels, respectively.

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