Fenofibrate Improved Interstitial Fibrosis of Renal Allograft through Inhibited Epithelial-Mesenchymal Transition Induced by Oxidative Stress

Figure 3

Fenofibrate recovered phenotypic changes induced by oxidative stress. (a, b) PPARα expression level assessed via quantitative RT-PCR and Western blot analysis in NRK-52e cells treated with H₂O₂ for 2 h and then with fenofibrate for 24 h. (c) Relative ROS and MDA levels after treatment with fenofibrate and H₂O₂. (d, e) Western blot and quantitative analysis for the expression of N-cadherin, S100A4, vimentin, collagen I, and Snail with ImageJ. , .

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