Lycorine Attenuates Autophagy in Osteoclasts via an Axis of mROS/TRPML1/TFEB to Reduce LPS-Induced Bone Loss

Table 1

Trabecular microarchitecture and biochemical markers of LPS with or without lycorine-treated mice.

	Vehicle (PBS)		LPS
	PBS	Lycorine	PBS	Lycorine
BMD (mg/cm^3)			^a	^b
BV/TV (%)			^a	^b
Tb.Th (μm)			^a	^b
Tb.Sp (μm)			^a	^b
CTX (ng/ml)			^a	^b
ALP (U/l)
OCN (ng/ml)
MCP-1 (pg/ml)			^a	^b

PBS (); LPS (dissolved in PBS, 5 mg/kg) (); LPS+lycorine (dissolved in PBS, 6 mg/kg) (); lycorine (). Data are represented as . Differences between groups were analyzed by two-way ANOVA, followed by Bonferroni posttests to compare the effect of lycorine (BMD, ; Tb.Th, ; BV/TV and CTX-1, ) and the effect of LPS (MCP-1, ; BMD, Tb.Th, Tb.Sp, and CTX-1, ) and interaction (BV/TV, Tb.Th, Tb.Sp, and MCP-1, ; BMD, ; CTX-1, ). ^a and ^a compared with vehicle-injected mice. ^b, ^b, and ^b compared with LPS-injected mice.