Tocotrienol-Rich Fraction (TRF) Treatment Promotes Proliferation Capacity of Stress-Induced Premature Senescence Myoblasts and Modulates the Renewal of Satellite Cells: Microarray Analysis

Table 3

GSEA analysis on the biological processes regulated by the TRF-posttreated SIPS cells as compared to the SIPS control ().

GO accession	Biological process	NES	value
GO:0009165	Nucleotide biosynthetic process	−1.36	1.85E − 02
GO:0006338	Chromatin remodeling	−1.76	1.85E − 02
GO:0046328	Regulation of JNK cascade	1.21	1.96E − 02
GO:0030968	Endoplasmic reticulum unfolded protein response	1.71	2.04E − 02
GO:0032069	Regulation of nuclease activity	1.65	2.04E − 02
GO:0016558	Protein import into peroxisome matrix	1.41	2.13E − 02
GO:0030259	Lipid glycosylation	1.56	2.22E − 02
GO:0090501	RNA phosphodiester bond hydrolysis	−1.64	2.22E − 02
GO:0071695	Anatomical structure maturation	1.39	2.27E − 02
GO:0032869	Cellular response to insulin stimulus	1.35	2.27E − 02
GO:0016049	Cell growth	1.55	2.38E − 02
GO:0019321	Pentose metabolic process	1.44	2.44E − 02
GO:2001241	Positive regulation of the extrinsic apoptotic signalling pathway in absence of ligand	1.29	2.44E − 02
GO:2001239	Regulation of the extrinsic apoptotic signalling pathway in the absence of ligand	1.24	2.44E − 02
GO:0032092	Positive regulation of protein binding	1.64	2.50E − 02
GO:0045599	Negative regulation of fat cell differentiation	1.29	2.56E − 02
GO:0071479	Cellular response to ionizing radiation	−1.37	3.17E − 02
GO:0006308	DNA catabolic process	−1.56	3.28E − 02
GO:0000082	G1/S transition of mitotic cell cycle	−1.77	3.28E − 02
GO:0044843	Cell cycle G1/S phase transition	−1.77	3.28E − 02
GO:0090025	Regulation of monocyte chemotaxis	1.52	3.57E − 02
GO:0046325	Negative regulation of glucose import	1.34	3.57E − 02
GO:0010800	Positive regulation of peptidyl-threonine phosphorylation	−1.28	3.57E − 02
GO:0007127	Meiosis I	−1.66	3.64E − 02
GO:0002689	Negative regulation of leukocyte chemotaxis	1.81	3.70E − 02
GO:0006534	Cysteine metabolic process	1.32	3.70E − 02
GO:0090231	Regulation of spindle checkpoint	−1.61	3.70E − 02
GO:1902850	Microtubule cytoskeleton organization involved in mitosis	−1.73	3.70E − 02
GO:0032200	Telomere organization	−1.88	3.70E − 02
GO:0071300	Cellular response to retinoic acid	1.26	3.77E − 02
GO:0006302	Double-strand break repair	−1.88	3.77E − 02
GO:0031064	Negative regulation of histone deacetylation	1.47	3.85E − 02
GO:0010155	Regulation of proton transport	1.37	3.85E − 02
GO:0032924	Activin receptor signalling pathway	−1.35	3.85E − 02
GO:0051181	Cofactor transport	1.62	3.92E − 02
GO:0000060	Protein import into nucleus, translocation	−1.71	3.92E − 02
GO:1902668	Negative regulation of axon guidance	1.67	4.00E − 02
GO:0043388	Positive regulation of DNA binding	1.39	4.00E − 02
GO:0043320	Natural killer cell degranulation	−1.34	4.00E − 02
GO:0010887	Negative regulation of cholesterol storage	1.62	4.08E − 02
GO:0032845	Negative regulation of homeostatic process	1.47	4.08E − 02
GO:0051896	Regulation of protein kinase B signalling	1.33	4.08E − 02
GO:0008334	Histone mRNA metabolic process	−1.69	4.08E − 02
GO:0097191	Extrinsic apoptotic signalling pathway	1.22	4.17E − 02
GO:0002686	Negative regulation of leukocyte migration	1.53	4.26E − 02
GO:0048706	Embryonic skeletal system development	1.36	4.26E − 02
GO:0097035	Regulation of membrane lipid distribution	1.35	4.26E − 02
GO:0061157	mRNA destabilization	−1.72	4.26E − 02
GO:2000615	Regulation of histone H3-K9 acetylation	−1.73	4.26E − 02
GO:0072528	Pyrimidine-containing compound biosynthetic process	−1.88	4.26E − 02
GO:1903036	Positive regulation of response to wounding	1.35	4.35E − 02
GO:1900746	Regulation of vascular endothelial growth factor signalling pathway	−1.53	4.35E − 02
GO:0009303	rRNA transcription	−1.45	4.41E − 02
GO:0045080	Positive regulation of chemokine biosynthetic process	1.88	4.44E − 02
GO:0008207	C21-steroid hormone metabolic process	1.69	4.44E − 02
GO:0050795	Regulation of behavior	1.51	4.44E − 02
GO:1902107	Positive regulation of leukocyte differentiation	1.28	4.44E − 02
GO:0017157	Regulation of exocytosis	1.16	4.44E − 02
GO:0007098	Centrosome cycle	−1.42	4.44E − 02
GO:0001946	Lymphangiogenesis	−1.43	4.48E − 02
GO:0050919	Negative chemotaxis	1.68	4.55E − 02
GO:0060338	Regulation of the type I interferon-mediated signalling pathway	1.65	4.55E − 02
GO:0050748	Negative regulation of the lipoprotein metabolic process	1.56	4.55E − 02
GO:0038031	Noncanonical Wnt signalling pathway via JNK cascade	1.53	4.55E − 02
GO:0010935	Regulation of macrophage cytokine production	1.49	4.55E − 02
GO:0060907	Positive regulation of macrophage cytokine production	1.40	4.55E − 02
GO:0034661	ncRNA catabolic process	−1.71	4.55E − 02
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	−1.59	4.62E − 02
GO:1902624	Positive regulation of neutrophil migration	1.69	4.65E − 02
GO:2000406	Positive regulation of T cell migration	1.63	4.65E − 02
GO:2000403	Positive regulation of lymphocyte migration	1.56	4.65E − 02
GO:1901725	Regulation of histone deacetylase activity	2.14	4.76E − 02
GO:1902667	Regulation of axon guidance	1.81	4.76E − 02
GO:0048841	Regulation of axon extension involved in axon guidance	1.73	4.76E − 02
GO:0050882	Voluntary musculoskeletal movement	1.51	4.76E − 02
GO:0042113	B cell activation	−1.19	4.76E − 02
GO:0072522	Purine-containing compound biosynthetic process	−1.29	4.76E − 02
GO:1901991	Negative regulation of mitotic cell cycle phase transition	−1.47	4.76E − 02
GO:0006919	Activation of cysteine-type endopeptidase activity involved in apoptotic process	−1.23	4.84E − 02
GO:2000757	Negative regulation of peptidyl-lysine acetylation	−1.80	4.84E − 02
GO:0035067	Negative regulation of histone acetylation	−1.83	4.84E − 02
GO:0007628	Adult walking behavior	1.94	4.88E − 02
GO:0021756	Striatum development	−1.31	4.92E − 02
GO:1901988	Negative regulation of cell cycle phase transition	−1.46	4.92E − 02
GO:0045185	Maintenance of protein location	−1.48	4.92E − 02
GO:0051053	Negative regulation of DNA metabolic process	−1.52	4.92E − 02
GO:0051258	Protein polymerization	−1.53	4.92E − 02
GO:0044774	Mitotic DNA integrity checkpoint	−1.68	4.92E − 02
GO:0009124	Nucleoside monophosphate biosynthetic process	−1.71	4.92E − 02
GO:0043487	Regulation of RNA stability	−1.75	4.92E − 02
GO:0034501	Protein localization to kinetochore	−1.82	4.92E − 02
GO:0000077	DNA damage checkpoint	−1.91	4.92E − 02
GO:0000079	Regulation of cyclin-dependent protein serine/threonine kinase activity	−2.01	4.92E − 02