Scaling and root planning and modified Widman flap procedure
N-Acetylcysteine (NAC) capsules (600 mg; Swanson Health Products Co., Fargo, ND, USA)
One-way ANOVA with post Dunnett tests
The use of adjunctive NAC resulted in a significant reduction in probing depths in the S-NAC group when compared to the S-nonNAC group at 3 months, but no statistically significant differences in GCF sRANKL levels were observed in the sites that underwent surgical treatment with or without NAC at different time intervals.
Paired -test for intragroup and Student’s independent -test for intergroup; ANCOVA
There was a significant improvement in the parameters of MGI, PI, BOP, IL-1β, and salivary uric acid, but the improvement in PPD and CAL parameters was not statistically significant.
Results show that lycopene is a promising treatment modality as an adjunct to full-mouth SRP of the oral cavity in patients with moderate periodontal disease.
Repeated measures ANOVA with post hoc Bonferroni test; independent sample -test
Green tea intake as a component of nonsurgical periodontal therapy is promising for superior and rapid resolution of the disease process. Green tea increases the total antioxidant capacity of GCF and plasma along with potent anti-inflammatory, astringent, and antiplaque effects.
Gel formulation was prepared from tea tree oil (TTO) (5%, Melaleuca alternifolia, Sigma®, Steinheim, Germany)
Paired -test and independent Student’s -test
The local delivery of TTO gel in case of chronic periodontitis may have some beneficial effects to augment the results of the conventional periodontal therapy.
The results show that PD and BI reduced significantly in both groups before and after SRP; this reduction in the intervention group was higher than the control group.
Parameters of total antioxidant capacity (TOAC) and glutathione-S-transferase (GST) in GCF
Scaling and root planning
Green tea dentifrice (1,4%)
Paired -test and independent Student’s -test, Wilcoxon test, and Mann–Whitney test
Green tea dentifrice use showed statistically significant improvements in GI, BOP, CAL, TAOC, and GST levels on intra- and intergroup comparisons at 4 weeks. The results of the present study assert the use of green tea dentifrice as an adjunct to SRP during the active and healing phases following periodontal therapy, thereby enhancing the clinical outcomes.
The use of coenzyme Q10 oral supplements as an adjunct to scaling and root planning showed significant reduction in gingival inflammation when compared to scaling and root planning alone.
There was significant improvement in all the indices in the group test as compared to the control group. Melatonin is a potential antioxidant, and the clinical improvement it showed was significantly superior to that of the standard control group.
There was a reduction in periodontal inflammation with an increase in the salivary uric acid levels seen in subgroups treated by antioxidants in both gingivitis and periodontitis groups.
Systemic and local SOD levels are lowered in periodontitis. Adjunctive vitamin E supplementation improves periodontal healing as well as antioxidant defense.
