The Research Progress of Host Genes and Tuberculosis Susceptibility

Table 3

Association of cytokines, chemokines, and susceptibility to TB.

Cytokine species	Polymorphic locus	Region	Relationship with TB	References
IFN-γ	+874A/T	Pakistan, Sicily, South Africa, China, Spain	Susceptible	[57–61]
IFN-γ	+874A/T	Turkey, Malawi, Caucasians, West Africa, South India, China	Unrelated	[62–67]
IL-10	-1082	Ghana	Unrelated	[68]
IL-12	Promoter, intron, 3UTR	Multizone	Inconsistent	[66, 69–72]
IL-6	rs1800796 C allele	China	Susceptible	[73]
IL-18	-137 G/C	China	Susceptible	[74]
IL-22	rs2227472, rs2227473, rs2227478, rs2227483, rs2227485	China	Susceptible	[75]
TNFRSF1B	rs3397	South Africa, Ghana	Antagonized	[76]
CCL2	-2258G/A (rsl024611)	Mexico, Korea	Susceptible	[35, 77]
		Brazil	Unrelated
CCL5	-28C>G	Asia, Arabs	Antagonized	[78]