Research Article
Dexmedetomidine Attenuates Orthotopic Liver Transplantation-Induced Acute Gut Injury via α2-Adrenergic Receptor-Dependent Suppression of Oxidative Stress
Figure 1
Blocking α2A-AR siRNA reversed the protective role of Dex on OLT-induced intestinal injury in rats. (a) Representative images showing the microscopic findings of intestines stained with hematoxylin and eosin in seven groups. Bar scale, 10 μm. (b) Chiu’s scoring quantitating the intestinal mucosal damage. (c–d) Immunohistochemistry staining of CD3 (c) and CD4 (d) in intestinal issues. Red arrow: positive cells. Data are represented as the , for each group. S: sham-operated group; M: the model group with OLT; D1: rats that were pretreated with 10 μg/kg before OLT; D2: rats that were pretreated with 50 μg/kg before OLT; B1: rats that received 500 g/kg atipamezole at 40 min before receiving 50 μg/kg Dex prior to OLT; B2: rats that received 50 g/kg ARC239 at 40 min before receiving 50 μg/kg Dex prior to OLT; B3: rats that received 1.5 mg/kg BRL-44408 at 40 min before receiving 50 μg/kg Dex prior to OLT. , compared to Group S; #, compared to Group M; $, compared to Group D2.
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